Abstract
Further chemical modification to identify more chemically stabilized EP4-receptor selective agonists was continued. As a result, a further two EP4-receptor selective agonists 5-thiaPGE(1) 2a, 10 and 9beta-chloroPGF(2) analogue 11 were discovered.
MeSH terms
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Animals
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Binding Sites
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CHO Cells / metabolism
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Cricetinae
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Cyclic AMP / agonists
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Cyclopentanes / chemical synthesis*
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Cyclopentanes / pharmacology*
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Drug Design
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Halogens / chemistry*
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Humans
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Ligands
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Mice
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Receptors, Prostaglandin E / agonists*
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Receptors, Prostaglandin E, EP4 Subtype
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Sensitivity and Specificity
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Sulfur / chemistry
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Sulfur Compounds / chemical synthesis*
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Sulfur Compounds / pharmacology*
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Thiophenes / chemical synthesis
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Thiophenes / pharmacology*
Substances
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2-(1-adamantylmethyloxycarbonylamino)-3-aminopropioninc acid
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Cyclopentanes
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Halogens
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Ligands
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PTGER4 protein, human
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Ptger4 protein, mouse
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Receptors, Prostaglandin E
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Receptors, Prostaglandin E, EP4 Subtype
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Sulfur Compounds
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Thiophenes
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Sulfur
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Cyclic AMP